Methylsulfonylmethane (MSM) is a natural organosulfur compound found in fruits, vegetables and grains and it is consumed worldwide as a non-toxic dietary food supplement. Some of its benefits: -Due to its anti-inflammatory action, it is used as a therapeutic agent for the effective treatment of inflammatory conditions, such as arthritis, alleviating arthritic symptoms and improving the physical function of patients. -MSM has also an anti-oxidant action and therefore it protects the human body by reducing the oxidative stress that can be caused following endurance exercise. -It is also suggested for the relief of seasonal allergic rhinitis symptoms. -Boswellia serrata is a well-known plant with a long history in herbal medicine due to its therapeutic properties. -Boswellia’s extract is used for the reduction of osteoarthritis pain and the improvement of the body’s physical and functional ability. -Harpagophytum procumbens (Devil’s Claw) is one of the most studied herbaceous plants, because it can affect key mechanisms that may lead to inflammatory conditions. -Its extract appeared effective as an analgesic in the reduction of arthritic symptoms, such as pain and stiffness. -Tanacetum parthenium, which is commonly known as feverfew, is also an herb used for medical purposes and specifically for the treatment of inflammatory disorders. -Nowadays, there are clinical data indicating that the compounds of feverfew extract exert anti-migraine properties, while contributing to smooth microcirculation. -The plant extract of Equisetum arvense, a perennial herb well-known as horsetail, has anti-oxidant and anti-inflammatory properties contributing to the regular microcirculation. -Meanwhile, due to its bioactive phytochemicals, it is considered an effective candidate for the treatment of osteoporosis and bone regeneration.